Théotime Grohens

I’m a post-doctoral researcher at the Center for Genomic Regulation in Barcelona, in the Weghorn lab.

Before that, I did my Ph.D. at INSA Lyon, in the Inria Beagle team. Even before, I studied at the École Normale Supérieure in Paris, where I obtained an M. Sc. in theoretical computer science, and an M. Sc. in ecology and evolution.

You can find my CV here, follow me on Twitter, or look at my code on GitHub and on the Inria GitLab.

You can reach me at theotime (.) grohens (@) crg (.) eu.

Research interests

My research interests focus on evolutionary biology, and especially mathematical and computational models of evolution.

I am currently working on understanding the selection pressures that are at work in cancer cells, and in particular on the interaction between cancer and the immune system.

During my Ph.D., I worked on understanding how epistatic interactions between different kinds of mutations help shape evolutionary dynamics, through the lens of the coupling between DNA supercoiling and gene transcription. In order to study this phenomenon under the light of evolution, I developed and used EvoTSC, a simulation aimed at understanding how the transcription-supercoiling coupling can shape bacterial genomes over evolutionary timescales.


Computational Biology


Programming Languages

PhD Thesis

Talks & Posters


During my Ph.D., I taught computer science at INSA Lyon, in the Biosciences and Computer Science departments, and at IUT Lyon 1.